右美托咪定：对术后胃肠功能的不良影响

myomectomy. Participants in elective laparoscopic hysteromyomectomy were enrolled with a single dose of 0.5 μg kg-1 dexmedetomidine or the same volume of placebo intrenously administered for 15 min, followed by continuous pumping of 0.2 μg kg-1 h-1 of corresponding drugs until 30 min before the end of surgery. The primary outcome was the time to first flatus. Secondary outcomes were the time to first oral feeding and the first defecation, the occurrence of flatulence, pain score and postoperative nausea and vomiting until 48 h after the surgery. Eventually, 106 participants (54 in dexmedetomidine group and 52 in placebo group) were included for final ysis. The time to first flatus (SD, 25.83 [4.18] vs 27.67 [3.77], P = 0.019), oral feeding time (SD, 27.29 [4.40] vs 28.92 [3.82], P = 0.044), the time to first defecation (SD, 59.82 [10.49] vs 63.89 [7.71], P = 0.025), abdominal distension (n%, 12 (22.2) vs 21 (40.4), P = 0.044), PONV at 24 h (n%, 10 (18.5) vs 19 (36.5), P = 0.037), NRS 6 h (3.15(0.68) vs 3.46 (0.87), P = 0.043) and NRS 12 h (3.43 (0.88) vs 3.85 (0.85), P = 0.014) of dexmedetomidine group were significantly shorter than those of the placebo group. Intraoperative dexmedetomidine reduced the time to first flatus, first oral feeding, and first defecation. These results suggested that this treatment may be a feasible strategy for improving postoperative gastrointestinal function recovery in patients undergoing laparoscopic hysteromyomectomy.

Figure 1 CONSORT flow diagram.

Figure 2 The intraoperative remifentanil consumption of the dexmedetomidine group was significantly lower than those of the control group. Meanwhile, intraoperative sufentanil consumption was similar. The dosages are presented as mean and standard deviation. DEX dexmedetomidine.

Figure 3 The postoperative pain scores of the dexmedetomidine group were significantly lower than those of the control group at 6 h and 12 h after surgery. The scores are presented as mean and standard deviation. DEX dexmedetomidine, NRS numeric rating scale. *P = 0.043, #P = 0.014.

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